El ejercicio físico puede producir estrés oxidativo en el individuo lo que pueden condicionar el riesgo cardiovascular en niños y adolescentes. Este estudio pretende analizar el estrés oxidativo según la fuerza muscular isométrica de las extremidades superiores en la edad pediátrica. Se estudiaron 70 niños sanos con edades entre 10 y 14 años, y se analizaron en saliva los lipoperóxidos (LPO), el glutatión reducido (GSH), la ratio GSH/LPO y la catalasa, como marcadores de estrés oxidativo. La muestra se dividió en dos grupos según una condición física superior o inferior medida a través de dinamometría manual (TKK 5110); se diferenció la serie en sujetos prepuberales y puberales. Se encontraron niveles significativamente inferiores de GSH y GSH/LPO en el grupo de niños con fuerza superior, y en los puberales con la mismas características; estos resultados podrían indicar la existencia de un mayor estrés oxidativo en esta situación. En conclusión, los mayores niveles de fuerza músculo esquelética, medida a través de dinamometría manual, posiblemente pueden estar asociados a un mayor estrés oxidativo en niños púberes con condición física musculoesquelética superior.

Palabras clave: estrés oxidativo; fuerza muscular isométrica; dinamometría manual; niños.

Abstract

Physical exercise can produce oxidative stress, this situation could contribute cardiovascular risk in children and adolescents. The following study tries to evaluate the oxidative stress produced according to the handgrip strength in infancy. 70 healthy male subjects, ages 10 to 14 years, were studied. In the saliva samples, lipoperoxides (LPO), reduced glutathione (GSH), glutathione/lipoperoxides ratio and catalase were analyzed as biomarkers of oxidative stress. Children were divided into two groups according to their handgrip strength (high or low) measured by handgrip strength (TKK 5110). The groups were also divided into prepubertal and pubertal subjects. We found GSH’s significantly low levels and of GSH/LPO in pubertal group with high handgrip strength. We could possibly conclude that the higher levels of handgrip strength could be associated with more oxidative stress in pubertal group with high fitness.

Key words: oxidative stress; handgrip strength; children.

doi:10.5232/ricyde2011.02205

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Referencias/references

Bentur, L.; Mansour, Y; Brik, R.; et al. (2006) Salivary oxidative stress in children during acute asthmatic attack and during remission. Respir Med, 100, 1195-1201.
doi:10.1016/j.rmed.2005.10.022
PMid:16321513

Barnekow-Bergkvist, M.; Hedberg, G.; Janlert, U.; & Jansson, E. (2001). Adolescent determinants of cardiovascular risk factors in adult men and women. Scand J Public Health, 29(3), 208-217.
doi:10.1177/14034948010290031001
PMid:11680773

Castro-Piñero, J.; Artero, E.G.; España-Romero, V.; Ortega, F.B.; Sjöström, M.; Suni, J., et al. (2010). Criterion-related validity of field-based fitness tests in youth: A systematic review. Br J Sports, 44(13), 934-043.
doi:10.1136/bjsm.2009.058321
PMid:19364756

Child, R.; Wilkinson, D.M.; Brown, S.; Fallowfield, J.L.; & Donnelly, A. (1998). Elevated serum antioxidant capacity and plasma malondialdehyde concentration in response to a simulated half-marathon run. Med Sci Sports Exerc, 30, 1603–1607
doi:10.1097/00005768-199811000-00008

Codoñer-Franch, P.; Boix-García, L.; Simó-Jordá, R.; Del Castillo-Villaescusa, C.; Maset-Maldonado, J.; & Valls-Bellés, V. (2010). Is obesity associated with oxidative stress in children? Int J Pediatr Obes, 5(1), 56-63.
doi:10.3109/17477160903055945
PMid:19565402

Gougoura, S.; Nikolaidis, M.G.; Kostaropoulos, I.A.; Jamurtas, A.Z.; Koukoulis, G.; & Kouretas, D. (2007). Increased oxidative stress indices in the blood of child swimmers. Eur J Appl Physiol, 100(2), 235-239.
doi:10.1007/s00421-007-0423-x
PMid:17333242

Hasselstrom, H.; Hansen, S.E.; Froberg, K.; & Andersen, L.B. (2002). Physical fitness and physical activity during adolescence as predictors of cardiovascular disease risk in young adulthood. Danish Youth and Sports Study. An eight-year follow-up study. Int J Sports Med, 23 Suppl 1, S27-31.
doi:10.1055/s-2002-28458
PMid:12012259

Hudson, M.B.; Hosick, P.A. McCaulley, G.O.; Schrieber, L.; Wrieden, J. McAnulty, S.R. Triplett, N.T.; McBride, J.M.; & Quindry, J.C. (2008). The effect of resistance exercise on humoral markers of oxidative stress. Med Sci Sports Exerc, 40(3), 542-548.
doi:10.1249/MSS.0b013e31815daf89

Janz, K.F.; Dawson, J.D.; & Mahoney, L.T. (2002). Increases in physical fitness during childhood improve cardiovascular health during adolescence: the Muscatine Study. Int J Sports Med, 23,15-21.
doi:10.1055/s-2002-28456
PMid:12012257

Ji, LL.(1993) Antioxidant enzyme response to exercise and aging. Med Sci Sports Exerc, 25, 225-231.
doi:10.1249/00005768-199302000-00011

Kara, E.; Gunay, M.; Cicioglu, I.; Ozal, M.; Kilic, M.; Mogulkoc, R.; & Baltaci, AK. (2010) Effect of zinc supplementation on antioxidant activity in young wrestlers. Biol Trace Elem Res, (1),55-63.
doi:10.1007/s12011-009-8457-z
PMid:19597720

McBride, J.M.; Kraemer, W.J. Triplett- McBride, T.; & Sebastianelli, W. (1998). Effect of resistance exercise on free radical production. Med Sci Sports Exerc, 30, 67–72
doi:10.1097/00005768-199801000-00010

Myers, J.; Prakash, M.; Froelicher, V.; Do, D.; Partington, S.; & Atwood, J.E. (2002). Exercise capacity and mortality among men referred for exercise testing. N Engl J Med, 346, 793–801.
doi:10.1056/NEJMoa011858
PMid:11893790

Nikolaidis, M.G.; Kyparos, A.; Hadziioannou, M.; Panou, N.; Samaras, L.; Jamurtas, A.Z.; & Kouretas, D. (2007). Acute exercise markedly increases blood oxidative stress in boys and girls. Appl Physiol Nutr Metab, 32(2), 197-205.
doi:10.1139/H06-097

Pérez-Navero, J.L.; Benítez-Sillero, J.D.; Gil-Campos, M.; Guillénn-del Castillo, M.; Tasset, I.; & Túnez, I. (2009). Cambios en biomarcadores del estrés oxidativo inducidos por la pubertad. An Pediatr (Barc), 70(5):424–428
doi:10.1016/j.anpedi.2009.01.019
PMid:18923182 PMCid:2909187

Powers, S.K.; Jackson, M.J. (2008). Exercise-induced oxidative stress: cellular mechanisms and impact on muscle force production. Physiol Rev, 88(4), 1243-1276.
doi:10.1152/physrev.00031.2007
PMid:14991263

Ramel, A.; Wagner, K.H.; & Elmadfa, I. (2004). Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men. Eur J Nutr, 43, 2–6
doi:10.1007/s00394-004-0432-z
PMid:11252061

Reid, M.B. (2001). Nitric oxide, reactive oxygen species, and skeletal muscle contraction. Med Sci Sports Exerc, 33(3), 371-376.
doi:10.1097/00005768-200103000-00006

Ruiz, J.R.; Ortega, F.B.; Gutiérrez, A.; Meusel, D.; Sjöström, M.; & Castillo, M.J. (2006). Health-related fitness assessment in childhood and adolescence; a European approach based on the AVENA, EYHS and HELENA studies. J Public Health, 14, 269–277.
doi:10.1007/s10389-006-0059-z
PMid:19158130

Ruiz, J.R.; Castro-Piñero, J.; Artero, E.G.; Ortega, F.B.; Sjöström, M. Suni, J.; & Castillo, M.J. (2009). Predictive validity of health-related fitness in youth: a systematic review. Br J Sports Med, 43(12), 909-923.
doi:10.1136/bjsm.2008.056499

Santos-Silva, A.; Rebelo, M.I.; Castro, E.M.; Belo, L. Guerra, A.; Rego, C. & Quintanilha, A. (2001). Leukocyte activation, erythrocyte damage, lipid profile and oxidative stress imposed by high competition physical exercise in adolescents. Clin Chim Acta, 306(1-2), 119-126.
doi:10.1016/S0009-8981(01)00406-5

Twisk, J.W.; Kemper, H.C.; & Van Mechelen, W. (2000). Tracking of activity and fitness and the relationship with cardiovascular disease risk factors. Med Sci Sports Exerc, 32(8), 1455-1461.
doi:10.1097/00005768-200008000-00014
PMid:12012262

Twisk, J.W.; Kemper, H.C.; & Van Mechelen, W. (2002). Prediction of cardiovascular disease risk factors later in life by physical activity and physical fitness in youth: general comments and conclusions. Int J Sports Med, 23, 44-49.
doi:10.1055/s-2002-28461
PMid:17341610

Yousefzadeh, G.; Larijani, B.; Mohammadirad, A. et al. (2006). Determination of oxidative stress status and concentration of TGF-beta 1 in the blood and saliva of osteoporotic subjects. Ann N Y Acad Sci, 1091, 142-150.
doi:10.1196/annals.1378.062

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